Self hosted. All in one instance: from v6 uninstall to v13.5.0-1 new install

The PHP scripts kaltura-sanity.sh runs will not work as they are w/o a valid CA.
That said, if you disable the SSL verification in admin.ini and batch.ini as I detailed before, the Admin Console and batch daemon and its workers should be able to function properly.
However, as mentioned before, it is really most recommended that you configure Apache and Nginx with a proper valid [not self signed] cert, key and CA. For testing, you can just skip SSL altogether. For Production [or any machine whose IP is mapped to real domain and is accessible from www, for that matter], you can use letsencrypt and obtain a valid cert for free.